Synthesis of Sulphanilamide

Aim

To synthesis and submit sulphanilamide from p-acetamido benzene sulphanilamide and calculate its percentage yield.

Principle

Sulphanilamide can be prepared by the reaction of P-acetamido benzene sulphanilamide with Hydrochloric acid or ammonium carbonate. The acetamido groups are easily undergoing acid catalysed hydrolysis reaction to form p-amino benzene sulphonamide.

Reaction

Requirements

• Resorcinol – 1.2 g
• Ethyl acetoacetate – 2.4 ml
• Conc. Sulphuric acid – 7.5 ml

Procedure

1.5 gm of 4- acetamido benzene sulphonamide is treated with a mixture of 1 ml of conc. Sulphuric acid was diluted with 2 ml water. This mixture is gently heated under reflux for 1 hour. Then 3ml of water is added and the solution is boiled again, with the addition of a small quantity of activated charcoal. The solution is filtered while hot, and the filtrate is neutralised with powdered sodium carbonate with stirring until all effervescence ceases and the sulphanilamide is precipitated as a white powder. The solution is cooled, filtered, the sulphanilamide washes with water and dried. Finally, crude sulphanilamide is recrystallized from hot water, to get colourless crystals.

Melting Point: 1630C

Category: Bacteriostatic agent

Report

The Sulphanilamide was synthesised and submitted, Reported the following

1. Theoretical Yield =
2. Practical Yield =
3. Percentage Yield =