Synthesis of Chlorbutanol

Aim

To Prepare and submit chlorobutanol from acetone and calculate the Percentage Yield.

Principle

Chlorbutanol is also known as Chloroketone. It is a trichloro derivative of tertiary butyl alcohol. It is prepared by combination with acetone and
chloroform in the presence of solid potassium hydroxide Chlorobutanol is used as a local anaesthetic in dental preparation and also antiseptic.

Reaction

Requirements

• Chloroform – 11 ml
• Potassium hydroxide – 1 gm
• Acetone – 14 ml

Procedure

About 11 ml of chloroform and 1 gm of solid potassium hydroxide are taken in a round bottom flask shake until the potassium hydroxide dissolves. To this 14 ml of acetone was added and shaken for 15 minutes. Then set aside for half an hour and the crystal of chlorobutanol were separated out.
Melting Point: 95oC – 99oC

Use: Local anaesthetics

Report

Chlorbutanol was Prepared and submitted and reported the following

1. Theoretical Yield =
2. Practical Yield =
3. Percentage yield =