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Aim: To study the effect of hepatic microsomal enzyme induction on the duration of action ofpentobarbital sodium. Principle: The drugs induce hepatic microsomal oxidative enzyme systems to enhance the metabolism of other drugs. as a result, in the presence of…
Aim: To study the anticonvulsant activity of phenytoin against maximal electro shock-inducedconvulsion rats. Principle: Different types of epilepsy i.e., grand mal, petit mal or psychomotor type, can be studied inlaboratory animals. The maximal electroshock (MES) induced convulsions in animals representgrand…
Aim: To study the central nervous system depressant property of chlorpromazine on the locomotor activity of mice using an actophotometer. Principle: Most of the central nervous system acting drugs influencing the locomotor activities in man and animals. The CNS depressant…
Aim: To study the muscle relaxant property of diazepam in mice using rotarod apparatus. Principle: One of the important pharmacological actions of anti-anxiety agents of benzodiazepam class of drugs is muscle relaxing property. The skeletal muscle relaxation together with a…
Aim: To study the effect of physostigmine and atropine on ciliary movement in frog buccalcavity. Principle: Cilia in the buccal cavity and in the oesophagus helps in the movement of food particles. Similarly, the importance of mucociliary function has been…
Aim: To study the Mydriatic effect of topically applied atropine on rabbit eyes. Principle: A large number of drugs are used for their local action in the eye as eye drops or eye ointments. Most of these drugs belong to…
There are different routes of drug administration by using laboratory animals. Aim: To learn how to handle, treat preparing animals for experiments and ethical guidelines during the treatment. Measure the required volume of drugs using aspectic techniques. To learn how…
In this post, we will learn about the different types of common laboratory animals which we often use in our Pharmacology Lab. Guinea pig Guinea pigs (400-600g) are the commonly used experimental animals. they are very docile and easy to…
In spite of tremendous development in electronic devices and recording systems are followed in institutions and research laboratories. Some common instruments are used in experimental pharmacology. Organ bath: The tissue bath used to put the animal tissue for studying the…
Aim: To find out the number of red blood cells in one cubic millimetre of blood. Principles: The number of RBC in a known volume of diluted blood is counted and the number ofcells in one cm of undiluted blood…