Amines MCQs with Answers of Pharmaceutical Organic Chemistry 2 B.Pharm 3rd Semester. All the Multiple Choice Questions and Answers share in this post are extremely helpful from an exam perspective so read and learn them all.
Amines MCQs with Answers | Pharmaceutical Organic Chemistry 2 | B.Pharm 3rd Semester
1. In the conversion of Benzene diazonium salt to Fluorobenzene, the catalyst used is
- Br2
- CuBr
- HBr
- Bromine water
Ans: CuBr
2. In the conversion of Benzene diazonium salt to Cyanobenzene, the catalyst used is
- HCN
- CuCN
- LiAlH4
- Cyanoacetic acid
Ans: CuCN
3. In the conversion of 2,4-dichloroBenzene diazonium salt to 2,4-dichlorbenzene, the catalyst used is
- NaOH
- H3PO2
- HCl
- KOH
Ans: H3PO2
4. Product of the Hofmann elimination reaction is
- Primary amine
- Secondary amine
- Tertiary amine
- ammonia
Ans: Tertiary amine
5. The catalyst used in the Hofmann rearrangement reaction is
- NaBr
- NaOBr
- HCl
- NaCl
Ans: NaOBr
6. Intermediate formed in the Hofmann rearrangement reaction is
- Isocyanate
- Cyanide
- Cyanate
- Isothocyanate
Ans: Isocyanate
7. Product of the Hofmann rearrangement reaction is
- Primary amine
- Secondary amine
- Tertiary amine
- Amide
Ans: Primary amine
8. Hofmann rearrangement reaction is also called as
- Migration to electron deficient carbon
- Migration to electron rich carbon
- Migration to electron deficient nitrogen
- Migration to electron rich nitrogen
Ans: Migration to electron deficient nitrogen
9. Stereochemistry in Hofmann rearrangement reaction is
- Inverstion of configuration
- Retention of configuration
- No sterochemistry is observed
- None of the above
Ans: Retention of configuration
10. In the orientation of Hofmann elimination reaction of quaternary salts, E2 transition state-observed is
- Carbocation like
- Carbanion like
- Alkene characte
- Alkane character
Ans: Carbanion like
12. Which of the following statements is false about primary amines?
- They can be prepared by reduction of nitriles with LiAlH4
- They do not form salts with acids.
- They react with ice-cold nitrous acid to form nitrogen gas.
- They are basic and soluble in water
Ans: They do not form salts with acids.
13. Which of the following statements is false about secondary amines?
- They react with chloroform and NaOH to form isocyanides.
- They can be prepared by reduction of isocyanides.
- They react with acid chlorides to give substituted amides.
- They react with ice-cold nitrous acid to give nitrosamine (yellow oil).
Ans: They react with chloroform and NaOH to form isocyanides.
14. The hybridization of nitrogen in an amine is
- sp
- sp3
- sp2
- sp4
Ans: sp3
15. Which of the following compounds is a secondary amine?
- H2NCH2CH2NH2
- CH3CH2NHCH3
- (CH3)3N
Ans: CH3CH2NHCH3
16. A sample of pure amine molecules is found to possess no intermolecular H-bonding. This sample is most likely :
- 1° amine
- 2° amine
- 3° amine
- all of the above
Ans: 3° amine
17. Which of the following is least soluble in water?
- Methylamine
- Trimethylamine
- Dimethylamine
- Aniline
Ans: Aniline
18. Which of the following is most soluble in water?
- CH3CH2CH3
- CH3CH2CH2Cl
- CH3CH2CH2NH2
Ans: CH3CH2CH2NH2
19. Which amine is NOT soluble in water?
- Methylamine
- Dimethylamine
- Trimethylamine
- All are water-soluble
Ans: All are water-soluble
20. Consider a 1°, 2° and 3° amine, all of the equivalent molecular weight. Which
amine is most likely to have the lowest boiling point?
- 1° amine
- 2° amine
- 3° amine
- None of the above
Ans: 3° amine
21. Which of the following will have the highest boiling point?
- Methylamine
- Diethylamine
- Ethylamine
- Triethylamine
Ans: Triethylamine
22. Which compound has the highest boiling point? 1.CH3CH2CH3 2. CH3CH2OH 3. CH3CH2NH2
- 1
- 2
- 3
- 2 and 3 have similar boiling points
Ans: 2
23. Which of the following has the highest boiling point?
- CH3CH2CH2CH3
- CH3CH2CH2CH2Cl
- CH3CH2CH2CH2NH2
- CH3CH2CH2CH2F
Ans: CH3CH2CH2CH2NH2
24. Amines are generally classified as
- Weak acids
- Strong acids
- Weak bases
- Strong bases
Ans: Weak bases
25. Acetamide reacts with Br2/NaOH to give
- Methylamine
- Urea
- Ethylamine
- Acetyl bromide
Ans: Urea
26. Reduction of an imine will give an
- Acid
- Amide
- Amine
- Alcohol
Ans: Amine
27. Which of the following is most basic?
- Ammonia
- Methylamine
- Dimethylamine
- Trimethylamine
Ans: Dimethylamine
28. The major product of the following reaction is :
- 1° amine
- 2° amine
- 3° amines
- amide
Ans: 3° amines
29. Aliphatic primary amines react with cold nitrous acid to form
- Alcohols
- Diazonium salts
- Nitriles
- Nitroalkanes
Ans: Alcohols
30. Which type of amine produces N2 when treated with HONO?
- Primary
- Secondary
- Tertiary
- Quaternary
Ans: Primary
31. Methylamine reacts with nitrous acid to form
- CH3CH3
- CH3OH
- CH3NO2
- CH3CH2OH
Ans: CH3OH
32. Which of the following compounds react with nitrous acid to form an
alcohol?
- CH3CH2NH2
- (CH3CH2)2NH
- (CH3CH2)3N
Ans: (CH3CH2)2NH
33. A nitrile can be made by dehydrating an amide. However, for this reaction to
occur, the amide must be :
- primary
- secondary
- tertiary
- N-methylated
Ans: primary
34. Which of the following amines react with nitrous acid to form nitrosamine?
- Ethylamine
- Triethylamine
- Diethylamine
- Isopropylamine
Ans: Diethylamine
35. Which of the following does not react with acyl chlorides to form amides :
- ammonia
- 1° amine
- 2° amine
- 3° amine
Ans: 3° amine
36. A primary amine can be identified by using
- HCl
- CHCl3
- NaOH
- CHCl3 + KOH
Ans: CHCl3 + KOH
37. Carbylamine test is given by
- Primary amines
- Secondary amines
- Tertiary amines
- None of the above
Ans: Primary amines
38. Carbylamine test involves heating a mixture of
- alcoholic KOH, methyl iodide, and sodium metal
- alcoholic KOH, methyl iodide, and primary amine
- alcoholic KOH, chloroform, and primary amine
- alcoholic KOH, methyl alcohol, and primary amine
Ans: alcoholic KOH, chloroform, and primary amine
39. Acetamide on heating with P2O5 gives :
- Methylamine
- Ethylamine
- Methyl cyanide
- None of the above
Ans: Methyl cyanide
40. Which of the following is formed in the reaction of an aldehyde and primary amine?
- Ketone
- Aromatic acid
- Schiff’s base
- Carboxylic acid
Ans: Schiff’s base
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