Free Download Pharmacogenetics PPT in

Download Pharmacogenetics PPT For Free. Pharmacogenetics is that the study of the genetic factors that influence drug response and toxicity.

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1. Overview of Pharmacogenetics PPT

• The study of genetically controlled variations in drug response.
• Pharmacogenetics is the special area of biochemical genetics that deals with variation in drug response and the contribution of genetics to such variation.
• Monogenic: due to allelic variation at a single gene
• Polygenic: due to variations at two or more gene
• Polymorphic: frequently occurring monogenic variants occurring at a frequency >1%

2. Pharmacogenetics and Pharmacogenomics

Contents of this PPT

• Background and Introduction
• Importance and Goals of Pharmacogenomics
• Pharmacogenetic Phenotypes
• Pharmacogenomic tests
• Pharmacogenetics & Drug development
• Pharmacogenetics in clinical practice
• Advantages and barriers of pharmacogenomics

3. Genetic Polymorphism in Drug Metabolism

• Genetic polymorphism is the variations in DNA sequences
• This explain some of the variability in drug- metabolizing enzyme activities which contribute to
• alterations in drug clearance and
• impact patients’ response to drug therapy

4. Drug Discovery and Development

• In the past most drugs have been discovered either by identifying the active ingredient from traditional remedies or by serendipitous discovery
• But now we know diseases are controlled at molecular and physiological level
• Also shape of an molecule at atomic level is well understood.
• Information of Human Genome

5. Aptamers Based Drug Delivery

• Aptamers are oligonucleotide or peptide molecules that bind to specific target molecule.
• Aptamers are usually created by selecting them from a large random sequence pool, but natural aptamers also exist in riboswitches.
• Aptamers can be combined with ribozymes to self-cleave in the presence of their target molecule.
• They range in size from 20 to 80 bases (6-26kda).

6. Personalized Medicines

• Personalized medicine. 
• Dosage forms for personalized medicine. 
• Categories of patients for personalized medicine.
• Customized drug delivery systems.
• 3D printing of pharmaceuticals. 
• Telepharmacy. 
• Bioelectric Medicines

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